APOE‐Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC‐K

Among older APOE 𝜀34 and 𝜀44 genotypes, lower meat consumption was associated with faster cognitive decline, while higher meat consumption resulted in similar cognitive change trajectories as those of APOE 𝜀22/23/24/33 genotypes. Our results support the hypothesis that the ancestral gene variant-APOE4-provides adaptation to meat consumption, at least from the perspective of cognitive health. Further studies on broader health outcomes and dementia conversion are warranted.