Donor‐Specific Modeling of Alzheimer's Disease Progression via Cell‐Type‐Aware Single‐Cell Representations
By learning donor-specific latent representations of AD progression, our model facilitates the investigation of relationships between molecular, cellular, and physiological changes throughout the disease course. This framework lays the groundwork for developing more personalized diagnostic and therapeutic strategies for Alzheimer's disease.
Authors
- Mariano I. Gabitto (ORCID: https://orcid.org/0000-0001-6911-344X)
- Anamika Agrawal (ORCID: https://orcid.org/0000-0002-1213-2321)
- Eitan S Kaplan (ORCID: https://orcid.org/0000-0002-9355-324X)
- Kyle J Travaglini
- Shubhabrata Mukherjee
- Hsin‐Yu Lai
- Andreas Tjaernberg
Institutions
- Allen Institute for Brain Science (US)
- University of Washington (US)
- Allen Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108378
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00