Dysfunctional Cellular Energy Metabolism is a Premorbid Characteristic of Late‐Onset Alzheimer's Disease

Overall, our data suggest that dysfunctional bioenergetics is an inherent cell-specific and cell-autonomous risk factor in LOAD. Together with findings in the brains of normally aging individuals or in patients with LOAD, the data support the view that in LOAD, inherent cell-metabolic dysfunctions may occur in development and early life altering the trajectory of the normal aging process already in youth and middle-age and predispose neuropathological events that lead to symptomatic features of LOAD in late life. Our studies seek to further identify and characterize the cellular mechanisms underlying LOAD-associated bioenergetic abnormalities. Results of these studies may reveal targets and methods for treating individuals at risk for LOAD before illness develops or delaying disease onset and progression later in life.