Investigating the Cascade of Immunological and Vascular Events in Amyloid Immunotherapy

In summary, our findings establish that anti-Aβ antibody engagement at CAA deposits initiates a complex inflammatory cascade involving perivascular macrophage activation, vascular remodeling, and increased vascular permeability. These immune responses contribute to the pathogenesis of microhemorrhages and may underlie ARIA. Further studies are needed to elucidate the functional roles of diverse macrophage subsets and their contributions to cerebrovascular injury in the context of Aβ immunotherapy.