Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging
Our work provides further evidence supporting protocol and processing standardization for minimizing machine-origin differences prior to considering harmonization. Differences in dMRI metrics seen when comparing across unstandardized protocols were reduced when protocols were standardized. NODDI metrics had more apparent sensitivity to site than DTI measures.
Authors
- Robert I. Reid (ORCID: https://orcid.org/0000-0003-2391-8650)
- Jonathan Graff‐Radford
- Nolan Meyer (ORCID: https://orcid.org/0000-0003-3566-896X)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Michael G. Kamykowski (ORCID: https://orcid.org/0000-0002-3108-7618)
- Arvin Arani (ORCID: https://orcid.org/0000-0001-6607-8781)
- M E Griswold
- C. R. Jack
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
- B Gwen Windham
- Kejal Kantarci
- Ronald Petersen
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109965
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00