Pattern of Regional Cerebral Metabolism before Onset of Clinically Evident Lewy Body Disease Differentially Predicts Future Lewy Body vs. Alzheimer’s Symptom Progression among Patients with Parietotemporal Hypometabolism at Baseline

Patients clinically non-LB but with LB-type cerebral metabolism at baseline developed more clinical LB features by one year and were more likely to suffer from ≥2 core LB symptoms by two years, including when matched for baseline number of core symptoms, while PCC/AVC ratios measured at the individual level correlated with degree of LB-symptom progression over subsequent years.