A proteomic tool suggests reductions in dementia risk following intentional weight loss in type 2 diabetes
These results support epidemiological evidence that non-pharmacological weight loss may protect against dementia risk, particularly in those with cardiometabolic features. Furthermore, the proteomic dementia risk test was robust to identifying changes in dementia risk in response to intentional weight loss. These findings suggest that the proteomic model has value to evaluate pharmacologic and non-pharmacological interventions to reduce dementia.
Authors
- Paul Welsh
- Michael E. J. Lean (ORCID: https://orcid.org/0000-0003-2216-0083)
- Clare Paterson (ORCID: https://orcid.org/0000-0001-7454-560X)
- Odette Chagoury (ORCID: https://orcid.org/0000-0002-1723-9056)
- Stephen A. Williams (ORCID: https://orcid.org/0000-0002-8661-4315)
- Jessica Chadwick (ORCID: https://orcid.org/0000-0002-2017-3094)
- Roy Taylor
- Shahrad Taheri
- Meredith Carpenter
- Naveed Sattar
- Brendan Epstein
Institutions
- Standard Bio (Norway) (NO)
- Weill Cornell Medical College in Qatar (QA)
- Hamad Medical Corporation (QA)
- Royal College of Physicians and Surgeons of Glasgow (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108444
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00