Lower Antemortem [ <sup>18</sup> F]flortaucipir PET retention in Males and Older Individuals is Explained by Lower Postmortem Tau Tangle Density
Comprehensive and independent PET, autopsy, and PET-to-autopsy analyses demonstrate that the associations between older age and male sex with lower Tau-PET uptake and prevalence are explained by lower tangle densities at autopsy. Tau-PET closely reflects postmortem tangle density, which explains the lower sensitivity of Tau-PET to detect Braak-V/VI tau at lower densities frequently observed in older and male individuals.
Authors
- Kevin Oliveira Hauer
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Sergey Shcherbinin (ORCID: https://orcid.org/0009-0003-9451-1230)
- Emma M. Coomans (ORCID: https://orcid.org/0000-0002-4289-9101)
- Daria Pawlik (ORCID: https://orcid.org/0000-0002-7646-4763)
- Elsmarieke van de Giessen
- Vikas Kotari (ORCID: https://orcid.org/0000-0002-4211-9400)
- Michael J. Pontecorvo (ORCID: https://orcid.org/0000-0002-8419-7589)
- S. Palmqvist
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Oskar H. Hansson
- Geidy E Serrano
- Niklas Mattsson‐Carlgren
- Ruben Smith
- Wiesje M. van der Flier
- Thomas G. Beach
Institutions
- Eli Lilly (United States) (US)
- Lund University (SE)
- Amsterdam Neuroscience (NL)
- Skåne University Hospital (SE)
- Banner Sun Health Research Institute (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110850
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00