Comparing Off‐Target Meningeal and Skull Signal in Head‐to‐Head MK‐6240 and AV‐1451 Tau PET
While off-target extra-cerebral signal appears in both tau PET tracers, it was more pronounced and wide-spread in 18F-MK-6240. Subject-specific skull and meningeal masks can parse this signal to aid in cause determination. Additional work is needed to explore factors contributing to this signal, such as demographic, health, and genetic.
Authors
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Thomas Hunter Smith
- Hope Shimony (ORCID: https://orcid.org/0000-0002-6245-2817)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Sarah Keefe (ORCID: https://orcid.org/0000-0002-5943-0940)
- Diana A. Hobbs (ORCID: https://orcid.org/0000-0001-7822-6411)
- Darrell Gray
- Jalen Scott (ORCID: https://orcid.org/0000-0003-1185-1882)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- David Soleimani‐Meigooni
- Jacqueline Rizzo
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Shaney Flores
- Brian A. Gordon
- Tammie L.S. Benzinger
- Yi Su
Institutions
- Universitat Autònoma de Barcelona (ES)
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Douglas Mental Health University Institute (CA)
- Hospital de Sant Pau (ES)
- University Memory and Aging Center (US)
- Banner Alzheimer’s Institute
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109929
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00