Cancer vaccine overcomes immune evasion of nasopharyngeal carcinoma by restoring MHC-I through transcriptional regulation of NLRC5
This study demonstrates that peptide-trained T cells can upregulate NLRC5 and MHC-I expressions on tumour cells, thereby restoring antigen presentation and enhancing tumour immunogenicity. These findings underscore the therapeutic potential of cancer vaccines in treating APM-downregulated NPC.
Authors
- Natalia Savelyeva (ORCID: https://orcid.org/0000-0002-7313-4769)
- Chai Phei Gan (ORCID: https://orcid.org/0000-0002-7075-5711)
- Prof. Sok Ching Cheong
- Kue Peng Lim (ORCID: https://orcid.org/0000-0002-5670-8070)
- Natasha Zulaziz
- Sau Yee Kok
- Bernard Kok Bang Lee
Institutions
- University of Liverpool (GB)
- Cancer Research Malaysia (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12967-025-07418-x
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Kementerian Sains, Teknologi dan Inovasi