Midlife and Later‐Life Environmental Risk Scores (ERSs) Modify the Associations of Apolipoprotein E ( <i>APOE</i> ) ε4 with Dementia
Associations of APOE were modified by midlife and later-life ERSs with dementia or MCI across diverse populations. Future research should include additional social and lifestyle measures, more genetic factors, consider the timing of the exposure measurements, and other phenotypes.
Authors
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Yuriko Katsumata (ORCID: https://orcid.org/0000-0002-0188-8094)
- Erin L. Abner (ORCID: https://orcid.org/0000-0002-9566-4111)
- Bryan D. James (ORCID: https://orcid.org/0000-0003-1932-151X)
- Inori Tsuchiya
- Khine Zin Aung (ORCID: https://orcid.org/0009-0000-3793-6927)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- X-C Wu
- Qiao Qi
- Xiaotong Ning
Institutions
- Rush University Medical Center (US)
- University of Kentucky (US)
- Rush University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108987
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00