Characterization of Coordinator Cis‐Regulatory Elements ‐ cCREs in the 5xFAD Mouse hypothalamus: Key regulators in Alzheimer's Disease
Our findings reveal a novel gene regulatory mechanism involving cCREs in the mouse hypothalamus that connects metabolism to AD risk. This research provides crucial insights into the impact of metabolic factors on AD progression and resilience, uncovering potential therapeutic targets at cCREs within AD risk loci.
Authors
- Christopher Gregg (ORCID: https://orcid.org/0000-0003-0819-1174)
- Josue D Gonzalez Murcia
- A. Cristina Rodriguez
- Pablo J Maldonado‐Catala
- Elliot Ferriss
Institutions
- University of Utah (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098093
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00