Identifying multimodal amyloid, tau, and neurodegeneration (ATN) subtypes in Alzheimer’s Disease across datasets and imaging markers
Our findings replicated the previously reported typical amyloid-first (ATN) subtype and tau-first subtype, but demonstrated that the typical amyloid-first subtype in fact consists of an early- and a late-tau subtype. These insights into the progression patterns of A, T, and N imaging biomarkers across datasets and radioligands may inform trials and understanding the heterogeneity of pathology trajectories.
Authors
- Nesrine Rahmouni
- Sean M. Nestor (ORCID: https://orcid.org/0000-0002-8848-5027)
- Katrina Carver (ORCID: https://orcid.org/0000-0001-5378-373X)
- Andrew Clappison (ORCID: https://orcid.org/0000-0003-3766-4452)
- JoAnne McLaurin
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Jennifer S Rabin
- Mario Masellis
- Serge Gauthier
- Dr Bojana Stefanovic
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Richard H. Swartz
- Min Su Kang
- Walter Swardfager
- Jean Chen
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Baycrest Hospital (CA)
- Ontario Brain Institute (CA)
- Artificial Intelligence in Medicine (Canada) (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108074
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00