The Utility of a Three-gene Host Response to Discriminate Tuberculous Meningitis From Other Infections in Children
The 3-gene host response signature does not discriminate TBM from controls in children and was much less discriminative compared to adults. An alternative set of pediatric-specific signatures may exist, but further discovery and validation are required.
Authors
- Suzanne T. Anderson (ORCID: https://orcid.org/0000-0003-1213-7787)
- Guy Edward Thwaites (ORCID: https://orcid.org/0000-0002-2858-2087)
- Samuel Ensor (ORCID: https://orcid.org/0000-0001-8456-9576)
- Tram Ngoc Pham
- Nguyễn Thụy Thương Thương (ORCID: https://orcid.org/0000-0001-8733-692X)
- A Griffiths
- Thu Anh Dang
- Trinh Huu Tung
- D. M. F. Gibb
- Julie Huynh (ORCID: https://orcid.org/0000-0002-9247-4267)
- Duc-Quang Vu (ORCID: https://orcid.org/0009-0008-6971-9140)
- Vinh Nguyen Dinh
- Nguyen Dinh Qui
- Van La Ngoc
- Trinh Thi Bich Tram
- Khanh Quoc Nguyen Phan
- on behalf of the SURE trial team
- Ny Hong Thi Tran
- Dang Minh Thi Ha
- Hai Thanh Hoang
- Bao Hoai Le Nguyen
- Nguyen Hong Thi Nhung
- Nhat Hoang Thanh Le
Institutions
- Apple (Israel) (IL)
- European Union (BE)
- Angkor Hospital for Children (KH)
- MRC Clinical Trials Unit at UCL (GB)
- Children's Hospital 2 (VN)
- Oxford University Hospitals NHS Trust (GB)
- Oxford University Clinical Research Unit (VN)
- Children's Hospital 1 (VN)
- Pham Ngoc Thach Hospital (VN)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1097/inf.0000000000005105
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00