Specific atrophy patterns distinguish tau and TDP‐43 pathology: a longitudinal MRI ante‐mortem study
We observed an anterior-posterior effect of TDP-43 and tau on the MTL with TDP-43 affecting anterior MTL volumes and tau posterior MTL volumes. Hippocampal head atrophy could help distinguish between AD patients with/without comorbid LATE.
Authors
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Lisa Quenon (ORCID: https://orcid.org/0000-0001-9139-2422)
- Yasmine Salman (ORCID: https://orcid.org/0000-0002-8564-5136)
- Sandra O. Tomé (ORCID: https://orcid.org/0000-0001-5253-0730)
- Julia Goloubeva
- Lara Huyghe
Institutions
- Statistics Belgium (BE)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110863
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00