Interictal Epileptiform Discharges and Alzheimer's Disease‐Associated Cortical Atrophy in Late‐Onset Epilepsy of Unknown Etiology
Patients with LOEU who develop dementia demonstrate decreased left posterior cingulate cortex volume. Interictal epileptiform discharges in LOEU are associated with bilateral medial temporal and parietal atrophy. Further work is needed to assess relationships between seizure onset location, atrophy patterns, and dementia risk in LOEU.
Authors
- Harika Kottakota
- Hsiang J. Yeh
- A J Fish (ORCID: https://orcid.org/0000-0002-8238-0240)
- Keith Vossel
- John M. Stern (ORCID: https://orcid.org/0000-0002-3549-1642)
- D SILVERMAN
- Haley Willem
- Adnan Muhammad Husein
- Mohit Bandla
- Noriko Salamon
- Corinne Allas
- Bhavya Pandey
- Lauren Herzog
- L. Brian Hickman
Institutions
- University of California, Los Angeles (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108284
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00