Vitamin K2 Protects Against Glucocorticoid-Induced Osteoporosis by Activating the NRF2/FSP1 Pathway to Inhibit Osteoblast Ferroptosis
VK<sub>2</sub> restores mitochondrial function and reduces lipid peroxidation and ferroptosis via the NRF2/FSP1 signaling pathway, thereby facilitating osteoblast differentiation and improving bone mass in GIOP mice. This finding not only provides a fresh perspective on the etiology of GIOP but also positions ferroptosis inhibition as a promising and innovative therapeutic strategy for this condition, with VK<sub>2</sub> emerging as a potential candidate for clinical translation.
Authors
- Y KOU
- Xing Rong
- Zhichao Zhang
- Minqi Li
- Jie Guo
- Qinghua Ren
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Jinan Stomatological Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s554610
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00