Metabolomic Changes After Bariatric Surgery Adjusted for Glomerular Filtration Rate Suggest Mechanisms of Kidney Protection
We discovered several GFR-independent metabolomic changes after bariatric surgery which may underlie its beneficial kidney effects including decreased inflammation, oxidation, and insulin resistance. Further studies are needed to investigate the potential mechanistic role of identified metabolites to clarify mechanisms of obesity-related kidney disease.
Authors
- Morgan E. Grams (ORCID: https://orcid.org/0000-0002-4430-6023)
- Jingsha Chen
- Tooraj Mirshahi (ORCID: https://orcid.org/0000-0002-0754-3820)
- Benjamin J. Apple (ORCID: https://orcid.org/0000-0002-7645-9550)
- Lesley A. Inker (ORCID: https://orcid.org/0000-0003-2820-9482)
- Alexander Chang (ORCID: https://orcid.org/0009-0002-4273-2595)
- C D Still
- Andrew S. Levey
- Josef Coresh
- Evan M. Zeitler
Institutions
- University of North Carolina at Chapel Hill (US)
- Tufts Medical Center (US)
- Geisinger Medical Center (US)
- Johns Hopkins University (US)
- University of Massachusetts Chan Medical School (US)
- Genomic Health (United States) (US)
- Optimal Solutions (United States) (US)
- Geisinger Health System (US)
- New York University (US)
Publication Details
- Journal
- Obesity
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1002/oby.70112
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases