Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2+ from childhood vaccinated women: The Trial23 cohort study
HPV16/18 vaccination reduced the risk of HPV16/18-related CIN2+ lesions, but a substantial burden remained from non-vaccine high-risk types. The substantial protection against HPV16/18-related CIN2+ and the consequential shift in HPV genotype distribution of CIN2+ among vaccinated women underline the need for adaptation of screening strategies.
Authors
- Mette Hartmann Nonboe
- Jeppe Bennekou Schroll (ORCID: https://orcid.org/0000-0002-1776-0562)
- Estrid Høgdall (ORCID: https://orcid.org/0000-0003-4689-5658)
- Jesper Bonde (ORCID: https://orcid.org/0000-0003-4853-6747)
- Sanne Christiansen
- Berit Andersen (ORCID: https://orcid.org/0000-0003-4074-6504)
- Anna Poulsgaard Frandsen (ORCID: https://orcid.org/0000-0002-1732-7283)
- Elsebeth Lynge
- George Napolitano
- Helle Pedersen
Institutions
- University of Copenhagen (DK)
- Aalborg University Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Gentofte Hospital (DK)
- Zealand University Hospital (DK)
- Hospital South West Jutland (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Vaccine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.vaccine.2025.128142
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Novo Nordisk
- Hvidovre Hospital
- Novo Nordisk Fonden