Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea
We observed higher within- and between-DMN FC in the CS-OSA compared to the CI-OSA group; however, this difference was not observed between the CS-nonOSA and CI-nonOSA groups. This result suggests a unique FC signature for individuals with DS and OSA prior to AD-related cognitive impairment. These findings suggest that there's a unique FC signature for individuals with DS and OSA such that FC is initially elevated prior to AD-related cognitive impairment then is reduced following AD symptom onset.
Authors
- Mithra Sathishkumar (ORCID: https://orcid.org/0000-0003-2572-9618)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Wayne Silverman (ORCID: https://orcid.org/0000-0002-7842-8600)
- Liv McMillan (ORCID: https://orcid.org/0000-0001-5077-7799)
- Jenna N. Adams (ORCID: https://orcid.org/0000-0002-6702-3851)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Natalie DiProspero
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- Eric Doran
- Lisa M. Taylor
- Nicole Schupf
- Mark Mapstone
- H. Diana Rosas
Institutions
- University of California, Irvine (US)
- Massachusetts General Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110032
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00