Personalization and network specificity of cerebellar TMS in schizophrenia

For personalized TMS, it is important to consider the targeted network, as well as the potential off-target network effects. Our findings demonstrate that cerebellar TMS has the strongest field effect on non-motor, cognitive and affective networks within the cerebellum. These results suggest cerebellar TMS may be ideal for schizophrenia symptoms unaddressed by pharmacological treatments, and effects may vary by individual network topology.

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Publication Details

Journal
medRxiv
Published
2025-12-22
DOI
https://doi.org/10.64898/2025.12.19.25342404
Primary Topic
Transcranial Magnetic Stimulation Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Personalization and network specificity of cerebellar TMS in schizophrenia

Madelaine Nye, Mark A. Halko, Isabella Demo, Emma Joncas et al.
medRxiv
Transcranial Magnetic Stimulation Studies
article

Personalization and network specificity of cerebellar TMS in schizophrenia

Madelaine Nye, Mark A. Halko, Isabella Demo, Emma Joncas, Rujuta Parlikar, Virginie‐Anne Chouinard, Roscoe O. Brady, Emily Payne, Moritz Dannhauer, Eunice Lee
article en

Abstract

For personalized TMS, it is important to consider the targeted network, as well as the potential off-target network effects. Our findings demonstrate that cerebellar TMS has the strongest field effect on non-motor, cognitive and affective networks within the cerebellum. These results suggest cerebellar TMS may be ideal for schizophrenia symptoms unaddressed by pharmacological treatments, and effects may vary by individual network topology.

medRxiv
Beth Israel Deaconess Medical Center (US), East Carolina University (US), McLean Hospital (US)
National Institutes of Health
Openalex Percentile: Top 39%
Transcranial Magnetic Stimulation Studies
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