Brain imaging‐derived phenotypes in an ethnically and socio‐economically diverse memory clinic population in South London
In general we found that volume of WMH was positively correlated with intra-axial CSF volumes but inversely related to cortical volumes. Hippocampal and cortical volumes were inversely correlated with CSF, as expected. Improving our understanding of imaging-derived phenotypes in routine clinical populations is crucial to the generalisability and applicability of potential future treatments for dementia. These results will form the basis for developing normative models including WMH data in a large-scale representative clinical population.
Authors
- Robert Leech (ORCID: https://orcid.org/0000-0002-5801-6318)
- František Váša (ORCID: https://orcid.org/0000-0001-6744-7139)
- Ashwin Venkataraman (ORCID: https://orcid.org/0000-0001-7977-1948)
- Clara Belessiotis‐Richards (ORCID: https://orcid.org/0000-0001-6900-2678)
- Gill Livingston
- Robert Stewart
Institutions
- Wellcome Centre for Human Neuroimaging (GB)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Central and North West London NHS Foundation Trust (GB)
- North East London NHS Foundation Trust (GB)
- Centre for Mental Health (GB)
- King's College School (GB)
- The London College (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108002
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00