Development of a simulation model of Alzheimer's Disease to evaluate disease modifying therapies in a memory clinic population
We developed a simulation model to evaluate amyloid-targeting therapies in MCI and mild dementia. The model can help quantify the effect of different treatment mechanisms and longitudinal consequences of treatment scenarios.
Authors
- Johannes Berkhof (ORCID: https://orcid.org/0000-0003-2094-2380)
- C. Teunissen
- Jeroen Hoogland (ORCID: https://orcid.org/0000-0002-2397-6052)
- Elsmarieke van de Giessen
- Hana M. Broulíková (ORCID: https://orcid.org/0000-0002-1662-3005)
- Ron L. H. Handels (ORCID: https://orcid.org/0000-0002-8663-0630)
- Everard G.B. Vijverberg (ORCID: https://orcid.org/0000-0003-3879-884X)
- Frederik Barkhof
- Wiesje M. van der Flier
- Argonde C. van Harten
- Pieter J. van der Veere
Institutions
- Queen Mary University of London (GB)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- Ministry of Health (CZ)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_104261
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00