Glial inflammation in the posterior white matter modulates the amyloid‐tau‐cognition relationship
Inflammation in the posterior WM, as quantified through TSPO-PET, modulated the relationship between amyloid and tau and between amyloid-related tau effects on cognitive dysfunction. These effects were beyond GM TSPO. Our findings highlight the importance of WM inflammation in the pathogenesis of AD.
Authors
- Henrik Zetterberg
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Nesrine Rahmouni
- Eric Yin (ORCID: https://orcid.org/0000-0002-9526-7490)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Kaj Blennow
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Serge Gauthier
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Andrea Benedet
- Thomas K Karikari
- Gleb Bezgin
- Min Su (Peter) Kang
- Sandra E. Black
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Sahlgrenska University Hospital (SE)
- Profu (Sweden) (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Ontario Brain Institute (CA)
- Banner Alzheimer’s Institute
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110037
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00