More than a sidekick: GIP signalling and cardiovascular outcomes
GIP/GIPR score Genetic proxy linked to lower BMI speci cally via GIP-signalling Polygenic BMI score 31 genetic variants linked to lower BMI in general Mendelian randomization Hazard ratio (95% con dence interval) per 1 kg/m 2 lower BMI 3-point MACE GIP/GIPR score Polygenic BMI score N total N events HR (95% CI) P value
Authors
- Florian Kahles
- Berkan Kurt
Institutions
- Universitätsklinikum Aachen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1093/eurheartj/ehaf944
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Foundation for the Study of Diabetes
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Novo Nordisk
- RWTH Aachen University
- Novo Nordisk Fonden
- European Research Area Network on Cardiovascular Diseases