Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm
The CPIO-EFLASH can achieve ultra-high dose rates (≥ 40 Gy/s at an SSD of 50 cm) and trigger significant normal tissue-sparing effects. Integrating electronic FLASH technology into intraoperative radiotherapy may bring potential clinical benefits by effectively treating tumors, while minimizing radiation-induced injury to normal tissues. Our findings highlight the necessity for further clinical trials of CPIO-EFLASH in intraoperative radiotherapy.
Authors
- Yihan Zhu (ORCID: https://orcid.org/0000-0002-8150-7350)
- Huan Du (ORCID: https://orcid.org/0000-0002-0020-149X)
- Binwei Lin
- Wei Wu (ORCID: https://orcid.org/0000-0001-5164-2765)
- Xiaobo Du
- Xiaofei Hao (ORCID: https://orcid.org/0000-0002-9554-3002)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-2274-429X)
- Dai Wu (ORCID: https://orcid.org/0000-0003-0319-5483)
- Yiwei Yang (ORCID: https://orcid.org/0000-0001-8845-440X)
- Jianxin Wang (ORCID: https://orcid.org/0000-0003-1528-5793)
- Yang Xia
- Decai Wang
- Mingming Tang
Institutions
- North Sichuan Medical University (CN)
- Southwest University of Science and Technology (CN)
- University of Electronic Science and Technology of China (CN)
- China Academy of Engineering Physics (CN)
- Mianyang Central Hospital (CN)
- Key Laboratory of Nuclear Radiation and Nuclear Energy Technology (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s13014-025-02781-x
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00