Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs

Malignant glandular epithelium lacked ERα expression in both dogs and men, with a notable shift from epithelial to stromal ERα expression in dogs during neoplastic transformation. Unlike in men, benign canine glands show diffuse ERα expression, whereas premature and atrophic glands display very low ERα levels. The observed differences in ERα expression across prostate tissue types in the dog -premature, normal, atrophic, and tumor-warrant further investigation to provide a clearer understanding of the role of ERα in PCa progression, particularly in castration-resistant cases. Such insights gained from the canine disease model may also help guide screening and management strategies for the growing population of young transgender women undergoing estrogen therapy and orchiectomy.

Authors

Institutions

Publication Details

Journal
The Prostate
Published
2025-12-23
DOI
https://doi.org/10.1002/pros.70111
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs

Sven Rottenberg, Emad A. Rakha, Mark A. Rubin, Catrin S. Rutland et al.
The Prostate
Prostate Cancer Treatment and Research
article

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs

Sven Rottenberg, Emad A. Rakha, Mark A. Rubin, Catrin S. Rutland, Alexander Dean, Simone de Brot, Jennifer Lothion‐Roy, Leonore Aeschlimann, Lea Anna Hiller, Nigel P. Mongan
article en

Abstract

Malignant glandular epithelium lacked ERα expression in both dogs and men, with a notable shift from epithelial to stromal ERα expression in dogs during neoplastic transformation. Unlike in men, benign canine glands show diffuse ERα expression, whereas premature and atrophic glands display very low ERα levels. The observed differences in ERα expression across prostate tissue types in the dog -premature, normal, atrophic, and tumor-warrant further investigation to provide a clearer understanding of the role of ERα in PCa progression, particularly in castration-resistant cases. Such insights gained from the canine disease model may also help guide screening and management strategies for the growing population of young transgender women undergoing estrogen therapy and orchiectomy.

The ProstateVol. 86(5)
University of Bern (CH), Bern University of Applied Sciences (CH), University of Nottingham (GB), Loughborough University (GB), Cornell University (US), Weill Cornell Medicine (US), Hamad Medical Corporation (QA)
University of Bern, National Institute for Health and Care Excellence, Albert-Heim-Stiftung, Biotechnology and Biological Sciences Research Council
Gender equality
Openalex Percentile: Top 29%
Prostate Cancer Treatment and Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.