The effect of topically applied Hesperidin on Imiquimod-induced Psoriasis in a mouse model

Psoriasis is a long-lasting, inflammatory autoimmune condition that primarily impacts the skin and mainly affects those with a significant genetic susceptibility. Hesperidin is a polyphenolic bioflavonoid belonging to the flavanone glycoside class, exhibiting antioxidant and anti-inflammatory actions. evaluate the effects of topical Hesperidin ointment alone and in combination with clobetasol propionate on Imiquimod-induced psoriasis in a mouse. 48 albino mice were divided into 6 groups, each of 8 mice. The effects of clinical observation, histopathological examination, and biomarker analysis were estimated. Hesperidin and its combination with clobetasol effectively diminished imiquimod-induced elevated PASI and Baker’s scores. Diminished inflammatory markers TNF-α, IL-6, and IL-17A, oxidative markers MDA and SOD. Topical administration of hesperidin may be a promising agent for psoriasis treatment alone or in combination with clobetasol. This is due to significant anti-inflammatory and antioxidant effects.