The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study

This study provides insights into the pathological processes that link GERD to PC. In addition, it offers a novel approach to PC prevention and early detection. In clinical practice, early screening and drug usage control in patients with GERD must be prioritised. Furthermore, dietary supplementation with n-3 PUFAs and proper n-6 PUFA reduction may minimise the prevalence of PC.