How do Recent Population-Level RSVpreF Vaccine-Impact Results from the United Kingdom Relate to Previously Reported Vaccine Effectiveness Results?

These early results indicate that the extent of expected population-level impact achieved can be reliably predicted from VE studies and national coverage data. Bivalent RSVpreF use can have a substantial public health and economic impact by reducing RSV-related hospitalizations, as seen in this initial UK vaccination program. Protection of older adults from severe RSV disease is off to a promising start and implementation efforts to boost vaccine uptake should be a priority for health care workers, public health practitioners, and policymakers.