<i>ALDH2 rs671</i> Variant Lowers Blood Pressure Via the Endothelial HSPA5–PIEZO1–eNOS Pathway
Our study provides definitive experimental evidence that <i>ALDH2</i> rs671 variation or endothelial <i>Aldh2</i> deficiency plays a protective role in BP regulation by activating the HSPA5-PIEZO1-endothelial nitric oxide synthase axis. We also revealed the previously unrecognized role of HSPA5 in maintaining PIEZO1 stability and BP regulation, providing a potential novel intervention target for hypertension therapy.
Authors
- C Zhang
- Wentao Sang (ORCID: https://orcid.org/0000-0002-2440-4486)
- Kehui Yang (ORCID: https://orcid.org/0000-0001-5135-9839)
- Huaqing Ye
- Yuguo Chen (ORCID: https://orcid.org/0009-0007-0910-0752)
- Sumei Cui
- Jingwen Wang (ORCID: https://orcid.org/0000-0003-1777-5307)
- Han Du
- Jialin Guo (ORCID: https://orcid.org/0000-0001-8056-994X)
- Kaiyi Wang
- Hongwei Yue
- Shujian Wei
- Yunyun Guo
- Feng Xu
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1161/jaha.124.040121
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00