Discovery and synthesis of (+)/(–)-muyoquinone A, a pair of rare cyclopropane bridge-containing pentacyclic benzoquinone dimers with cytotoxic activity

This work reports the structures, total synthesis via the Diels–Alder cascade reaction and cytotoxic activity of (±)-muyoquinone A, a pair of rare pentacyclic benzoquinone dimers isolated from the endophytic fungus Muyocopron laterale .

Authors

Yun-bao Liu
Yun‐Bao Liu (ORCID: https://orcid.org/0000-0002-1338-0271)
Cheng Yi
Yu-Wei Niu
Keliang Chen
Hai-Yan Cao
Yang Liu
Fangfang Lai

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Peking University (CN)

Publication Details

Journal: Organic Chemistry Frontiers
Published: 2025-12-23
DOI: https://doi.org/10.1039/d5qo01312g
Primary Topic: Microbial Natural Products and Biosynthesis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Discovery and synthesis of (+)/(–)-muyoquinone A, a pair of rare cyclopropane bridge-containing pentacyclic benzoquinone dimers with cytotoxic activity

Yun-bao Liu, Yun‐Bao Liu, Cheng Yi, Yu-Wei Niu et al.

Dec 23, 2025

Organic Chemistry Frontiers

Microbial Natural Products and Biosynthesis

article

Discovery and synthesis of (+)/(–)-muyoquinone A, a pair of rare cyclopropane bridge-containing pentacyclic benzoquinone dimers with cytotoxic activity

Yun-bao Liu, Yun‐Bao Liu, Cheng Yi, Yu-Wei Niu, Keliang Chen, Hai-Yan Cao, Yang Liu, Fangfang Lai

December 23, 2025article en

Abstract

This work reports the structures, total synthesis via the Diels–Alder cascade reaction and cytotoxic activity of (±)-muyoquinone A, a pair of rare pentacyclic benzoquinone dimers isolated from the endophytic fungus Muyocopron laterale .

Organic Chemistry FrontiersVol. 13(3)

Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN)

Openalex Percentile: Top 31%

Microbial Natural Products and Biosynthesis

DOI Source OpenAlex

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