From trigeminal ganglion to cortex: ATG7 emerges as a key integrator of migraine pathways via multi-omics profiling
Our study provides novel insights into migraine's central and peripheral mechanisms, highlighting cell-type-specific genetic contributions and potential therapeutic targets. The integrative framework combining snRNA-seq, eQTL, GWAS, and MR enhances the understanding of migraine biology and accelerates drug discovery, offering a pathway toward more effective treatments.
Authors
- Binghao Cao (ORCID: https://orcid.org/0009-0009-9810-8071)
- Yine Song
- Jiangyan Wei
- Lu Liu (ORCID: https://orcid.org/0000-0002-1091-6990)
- Y B Liu
- Chengcheng Zhang (ORCID: https://orcid.org/0000-0002-2992-6291)
- Yuancan Pan (ORCID: https://orcid.org/0000-0002-9844-2151)
- Libin Zheng
Institutions
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s10194-025-02222-w
- Citations
- 1
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47