Renal Case Chronicles – A Case Series on the Evolving Landscape of Membranoproliferative Glomerulonephritis

Abstract Membranoproliferative glomerulonephritis (MPGN), though rare, poses challenges in diagnosis and treatment. MPGN is a histologic lesion and not a specific disease entity. The pathological diagnosis of MPGN prompts the clinician for immediate and specific diagnostic intervention. Formerly, it was classified into type I, type II, and type III depending on the electron microscopic findings, which is obsolete now due to the overlapping features between type I and type III. Recently, the classification of membranous proliferative glomerulonephritis has been updated and is constructed upon the distinct pathogenetic process and direct immunofluorescence findings. Our illustrative case series fulfills the criteria of each three recent pathogenetic distinctive subtypes with a brief overview of the underlying pathogenesis, clinical presentation, and diagnosis of MPGN based on the light microscopy and direct immunofluorescence findings.