Synthesis-enabled conformational assignment of natural <i>N</i> -acyl <scp>l</scp> -phenylalanine derivatives from freshwater sponge–associated <i>Micromonospora</i> sp. MS-62
This study demonstrates a concise four-step total synthesis of <i>N</i>-acyl-L-phenylalanine derivatives (P1-P5) from <i>Micromonospora</i> sp. MS-62 enabling definitive assignment of the <i>S</i> configuration at C-1' <i>via</i> single-crystal X-ray diffraction. This synthesis clarifies the stereochemistry of this natural product class and facilitates future exploration of structure-activity relationship.
Authors
- Y H Kim
- Jaeyoung Kwon (ORCID: https://orcid.org/0000-0002-6729-0837)
- Yong Han (ORCID: https://orcid.org/0000-0002-4741-9058)
- Young-Joo Kim
- Jiyool Kim
- Jueun Kang
- Jinchan Sim
- Taejung Kim
- Young Tae Park
Institutions
- National Institute of Biological Resources (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1039/d5ob01886b
- Primary Topic
- Synthesis and Biological Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00