Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy
This proof-of-concept study highlights MRT as a promising non-invasive therapy for drug-resistant focal epilepsies with optimal peak doses of 125-250 Gy, and it suggests that distributing the dose through multiple angles optimizes the therapeutic effect. MRT could provide a safer alternative to surgery, warranting further investigations.
Authors
- Raphaël Serduc (ORCID: https://orcid.org/0000-0003-3294-8544)
- Antoine Depaulis (ORCID: https://orcid.org/0000-0001-6543-6700)
- Emmanuel Luc BARBIER
- Sarvenaz Keshmiri (ORCID: https://orcid.org/0000-0002-1810-4217)
- Paolo Pellicioli (ORCID: https://orcid.org/0000-0003-3590-116X)
- Loan Samalens (ORCID: https://orcid.org/0000-0002-3596-231X)
- Camille Beets
- Jean‐François Adam
- Clothilde Courivaud
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- European Synchrotron Radiation Facility (FR)
- Stanford Synchrotron Radiation Lightsource (US)
- Agir Pour les Maladies Chroniques (FR)
- Grenoble Institute of Neurosciences (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1002/epi.70063
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale