Find HDV and Determine Its Status in Türkiye “SITU(HD)VATION TÜRKİYE”

Objectives: Hepatitis delta virus (HDV) infection is detectable in hepatitis B surface antigen (HBsAg) positive patients and is more significant than other viral hepatitis in terms of the risk of liver cirrhosis/liver cancer.This study aimed to determine the prevalence of HDV and the clinical and histological status of patients with HDV in the southeastern region of Trkiye.Materials and Methods: A total of 250 family physicians in the provinces of Diyarbakr, anlurfa, Batman, and Mardin were trained on the importance of HDV infection and the follow-up of patients with HBsAg positivity.The importance of HDV was emphasised.For this purpose, the importance of prospectively screening 20,000 HBsAg-positive patients under the care of family physicians for HDV was highlighted.Human immunodeficiency virus (HIV) testing was also conducted in patients who tested positive for anti-delta.Patients who tested positive for HDV were referred to gastroenterology/infectious diseases specialists.Liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) values were measured using Fibroscan in patients who tested positive for HDV.Results: A total of 20,000 HBsAg-positive patients were included in the study.The mean age of the patients was 38.2 years; 64.3% of the patients were male.Anti-delta seropositivity was detected in 1,019 (5.1%) of HBsAg-positive patients.Patients with anti-Z Ama: Hepatit delta virs (HDV) enfeksiyonu, hepatit B yzey antijeni (HBsAg) pozitif bireylerde saptanabilmekte olup, siroz ve hepatoseller karsinom geliimi asndan dier viral hepatitlere kyasla daha yksek riskle ilikilidir.Bu almann amac, Trkiye'nin Gneydou blgesinde HDV prevalansn ve HDV ile enfekte hastalarn klinik/histolojik durumlarn ortaya koymaktr.Gere ve Yntemler: Diyarbakr, anlurfa, Batman ve Mardin illerinde grev yapan toplam 250 aile hekimine, HBsAg pozitif hastalarda HDV enfeksiyonunun nemi ve izlemi konusunda eitim verilmitir.Bu kapsamda, aile hekimlii izleminde bulunan 20.000 HBsAg pozitif hastann prospektif olarak HDV asndan taranmasnn gereklilii vurgulanmtr.Anti-delta pozitif saptanan hastalara ayrca insan immn yetmezlik virs (HIV) testi uygulanmtr.HDV pozitif olgular gastroenteroloji/enfeksiyon hastalklar uzmanlarna ynlendirilmitir.HDV pozitif hastalarda karacier sertlik lm (LSM) ve kontroll atenasyon parametresi (KAP) deerleri Fibroscan ile deerlendirilmitir.