Genomic and phylogenetic characterization of human-adapted methicillin-resistant <i>Staphylococcus aureus</i> clonal complex 398 lineages in Taiwan
This study reveals two human-adapted methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) CC398 lineages in Taiwan: ST1232 and ST398. ST1232 carried Panton-Valentine leukocidin, immune evasion cluster (IEC), and <i>radC</i>::Tn<i>554</i>, while ST398 retained IEC and exhibited SCCmec variability. These findings highlight the public health importance of monitoring emerging MRSA lineages.
Authors
- R. W. C. Li
- Tsung-Hua Wu (ORCID: https://orcid.org/0000-0003-2767-4526)
- Yu-Ping Fang
- Yu-Ying Yang
- YL Wu
- Mei-Hsiu Wan
- Yu-Fen Chang
- Chun-Yi Lee
- Ying-Tsong Chen
- Wen-Sheng Yeh
Institutions
- International Baccalaureate (CH)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1128/spectrum.02090-25
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00