Hybrid optogenetic and electrical stimulation of retinal ganglion cells for artificial vision
Combining the optogenetic and electrical modes of activation enabled significant reductions of each component in the stimulus, leading to more localised stimulation when compared to electrical-only stimulation, while also reducing the optical intensity required for optogenetic activation. Together with improvements in response reliability, hybrid stimulation may not only improve the resolution and refresh rate of future visual prostheses but may also provide greater control in neuromodulation for any bionic device that interfaces with neural tissue.
Authors
- Tatiana Kameneva (ORCID: https://orcid.org/0000-0003-0081-8569)
- Paul R. Stoddart (ORCID: https://orcid.org/0000-0003-4882-9400)
- Michael R. Ibbotson (ORCID: https://orcid.org/0000-0002-3803-6653)
- Rachael T. Richardson (ORCID: https://orcid.org/0000-0002-2412-8354)
- Wei Tong (ORCID: https://orcid.org/0000-0002-3725-2928)
- James M. Begeng (ORCID: https://orcid.org/0000-0002-8356-9336)
- Toon Goris (ORCID: https://orcid.org/0000-0002-6117-750X)
- Emma Brunton (ORCID: https://orcid.org/0000-0002-8877-9164)
- William C. Kwan
Institutions
- Bionics Institute (AU)
- The University of Melbourne (AU)
- Australian Regenerative Medicine Institute (AU)
- Swinburne University of Technology (AU)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.brs.2025.103012
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian College of Optometry
- Australian Government
- State Government of Victoria
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council