Explosive shock wave exposure leads to age-accelerated motor and sensory decline in <i>C. elegans</i>
Defined shock wave exposure is sufficient to provoke long-term neuronal functional decline in <i>C. elegans</i>, accompanied by structural deterioration and premature neurodegeneration. This tractable model enables lifelong phenotyping and mechanistic dissection of how an acute shock wave insult progresses to chronic neuronal dysfunction, and provides a scalable platform for identifying molecular and pharmacological modifiers that promote resilience.
Authors
- Dennis Grasse
- Daniel Krentel
- Nirav Barapatre (ORCID: https://orcid.org/0000-0003-4777-8234)
- Carmen I. Nussbaum-Krammer (ORCID: https://orcid.org/0000-0002-8689-1363)
- Jessica Tittelmeier (ORCID: https://orcid.org/0000-0002-8202-3702)
- S. Grobert
- Henrik Seeber
- Christoph Schmitz
Institutions
- Federal Ministry of Defence (DE)
- Federal Institute For Materials Research and Testing (DE)
- Helmut Schmidt University (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.19.695190
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00