Mechanistic insights into the antiproliferative effect of the redox-active iron chelator Dp44mT on multiple myeloma cell lines
This study suggests an in vitro, anti-multiple myeloma effect of Dp44mT that appears to be mediated by dysregulated iron metabolism, reactive oxygen species, and other biological pathways.
Authors
- Latha Pathangey
- Sinto Sebastian Chirackal
- Sundararaman Swaminathan
- Rafael Hinojal Fonseca
- Kiran K. Mangalaparthi
- Aarti Sharma
- Akhilesh Pandey
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Hematology Transfusion and Cell Therapy
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.htct.2025.106233
- Primary Topic
- Metal-Catalyzed Oxygenation Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00