Synthesis of Unsymmetrical Dialkyl Ethers via Direct Etherification Cocatalyzed Using FeCl <sub>3</sub> ·6H <sub>2</sub> O and 1,1,1,3,3,3-Hexafluoroisopropanol

Herein, a mild and efficient method for synthesizing unsymmetrical dialkyl ethers via direct etherification promoted by FeCl<sub>3</sub>·6H<sub>2</sub>O and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is described. Carbocations produced from alcohols, cocatalyzed using FeCl<sub>3</sub>·6H<sub>2</sub>O and HFIP, resulted in unsymmetrical dialkyl ethers through a unimolecular nucleophilic substitution mechanism. Unsymmetrical dialkyl thioethers could also be efficiently prepared using a similar approach.

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Publication Details

Journal
ACS Omega
Published
2025-12-22
DOI
https://doi.org/10.1021/acsomega.5c10269
Primary Topic
Sulfur-Based Synthesis Techniques
Type
article
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article

Synthesis of Unsymmetrical Dialkyl Ethers via Direct Etherification Cocatalyzed Using FeCl 3 ·6H 2 O and 1,1,1,3,3,3-Hexafluoroisopropanol

Pu Zhang, Zhi-Xin Guo, Zhu-Cai Yang
ACS Omega
Sulfur-Based Synthesis Techniques
article

Synthesis of Unsymmetrical Dialkyl Ethers via Direct Etherification Cocatalyzed Using FeCl 3 ·6H 2 O and 1,1,1,3,3,3-Hexafluoroisopropanol

Pu Zhang, Zhi-Xin Guo, Zhu-Cai Yang
article en

Abstract

Herein, a mild and efficient method for synthesizing unsymmetrical dialkyl ethers via direct etherification promoted by FeCl<sub>3</sub>·6H<sub>2</sub>O and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is described. Carbocations produced from alcohols, cocatalyzed using FeCl<sub>3</sub>·6H<sub>2</sub>O and HFIP, resulted in unsymmetrical dialkyl ethers through a unimolecular nucleophilic substitution mechanism. Unsymmetrical dialkyl thioethers could also be efficiently prepared using a similar approach.

ACS OmegaVol. 11(1)
Renmin University of China (CN)
Clean water and sanitation
Openalex Percentile: Top 34%
Sulfur-Based Synthesis Techniques
DOIOpen Access PDFOpenAlex
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