Cerebrospinal fluid α-synuclein seed amplification assay positivity is associated with increased plasma neurofilament light chain in Alzheimer's disease
In AD patients, CSF synSAA positivity is associated with increase of plasma NfL levels along the AD clinical continuum. This finding supports the knowledge that synuclein co-pathology represents a contributive factor of neurodegeneration in AD patients.
Authors
- Andrea Toja (ORCID: https://orcid.org/0009-0000-9500-7632)
- Davide Chiasserini (ORCID: https://orcid.org/0000-0002-1169-3258)
- Giovanna Nardi (ORCID: https://orcid.org/0009-0008-9123-9944)
- Lorenzo Gaetani (ORCID: https://orcid.org/0000-0003-3967-8954)
- Lucilla Parnetti
- Federico Paolini Paoletti
- Giovanni Bellomo
Institutions
- University of Perugia (IT)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1016/j.nbd.2025.107234
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00