Impact of androgen receptor pathway inhibitors on cognitive function in older adults treated for metastatic prostate cancer
Although limited by small sample sizes, our study shows that ARPI + ADT can increase the risk of impacting objective and subjective cognition in older adults with mPC, compared to ADT alone. Clinician should use specific measures of objective and subjective cognition to assess ARPI-induced cognitive changes.
Authors
- Amélie Darlix (ORCID: https://orcid.org/0000-0003-1384-1709)
- Karim S. Fizazi (ORCID: https://orcid.org/0000-0002-6068-9474)
- E. Meyer
- Philippe Beuzeboc (ORCID: https://orcid.org/0009-0005-1226-2678)
- Bénédicte Clarisse (ORCID: https://orcid.org/0000-0002-0543-732X)
- Justine Lequesne
- Mathieu Boone (ORCID: https://orcid.org/0000-0002-9228-6047)
- Sophie Gouérant
- Raffaele Ratta (ORCID: https://orcid.org/0000-0002-2445-415X)
- François Christy (ORCID: https://orcid.org/0009-0009-1519-8260)
- Florence Joly
- Giulia Baciarello (ORCID: https://orcid.org/0000-0002-5396-5071)
- Alexandra Leconte
- Marie Lange
- Pierre-Emmanuel Brachet (ORCID: https://orcid.org/0000-0003-3303-2634)
- Nedjla Allouache
- Antoine Boué
- Estelle Guerdoux
Institutions
- Inserm (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Centre François Baclesse (LU)
- Centre François Baclesse (FR)
- Cancers et Préventions (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Hôpital Foch (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1038/s43856-025-01302-x
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Astellas Pharma
- Institut National Du Cancer