Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3

These findings validate the use of simplified spherical models for CA20948 cells but highlight the importance of a correct estimation of the cell dimensions.

Authors

Lara Struelens
Kaat Spoormans (ORCID: https://orcid.org/0000-0003-3043-200X)
Melissa Crabbé (ORCID: https://orcid.org/0000-0002-3706-6914)
Michel Koole

Institutions

Belgian Nuclear Research Centre (BE)
KU Leuven (BE)

Publication Details

Journal: EJNMMI Physics
Published: 2025-12-23
DOI: https://doi.org/10.1186/s40658-025-00823-7
Primary Topic: Mathematical Biology Tumor Growth
Type: article
Field-Weighted Citation Impact: 0.00

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article

Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3

Lara Struelens, Kaat Spoormans, Melissa Crabbé, Michel Koole

Dec 23, 2025

EJNMMI Physics

Mathematical Biology Tumor Growth

article

Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3

Lara Struelens, Kaat Spoormans, Melissa Crabbé, Michel Koole

December 23, 2025article en

Abstract

These findings validate the use of simplified spherical models for CA20948 cells but highlight the importance of a correct estimation of the cell dimensions.

EJNMMI PhysicsVol. 13(1)

Belgian Nuclear Research Centre (BE), KU Leuven (BE)

Openalex Percentile: Top 35%

Mathematical Biology Tumor Growth

DOI Open Access PDF OpenAlex

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Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3 — Lara Struelens, Kaat Spoormans, et al. · EJNMMI Physics (2025) | TGRS Research Map | TGRS