Axon initial segment dynamics during associative fear learning
The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
Authors
- Chloé M Benoit (ORCID: https://orcid.org/0000-0003-2634-2650)
- Sabrina Milena Innocenti
- Jan Gründemann (ORCID: https://orcid.org/0000-0002-3149-0001)
- Ricardo Paricio-Montesinos (ORCID: https://orcid.org/0000-0003-3325-9038)
- Maren Engelhardt (ORCID: https://orcid.org/0000-0001-8020-6604)
- Dan A Ganea (ORCID: https://orcid.org/0000-0003-2558-8202)
- Andreas Lüthi
- Andrea Sattin (ORCID: https://orcid.org/0000-0002-1345-2204)
- Sabine Krabbe (ORCID: https://orcid.org/0000-0002-5735-469X)
- Jan Maximilian Janssen (ORCID: https://orcid.org/0000-0002-3818-7910)
- Tommaso Fellin
- Julia Esser
- Christian Thome
Institutions
- Johannes Kepler University of Linz (AT)
- University of Bonn (DE)
- University of Basel (CH)
- German Center for Neurodegenerative Diseases (DE)
- Italian Institute of Technology (IT)
- Department of Biomedicine Basel (CH)
- Friedrich Miescher Institute (CH)
Publication Details
- Journal
- Nature Neuroscience
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1038/s41593-025-02152-5
- Citations
- 1
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Science Foundation
- Universität Basel
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Deutsches Zentrum für Neurodegenerative Erkrankungen