A novel method for Tn antigen detection based on chemoenzymatic targeted labelling and CuAAC click chemistry
The Tn antigen is a key tumor-associated antigen and a promising cancer biomarker. However, its low abundance poses great challenges for sensitive detection. We developed a novel approach that integrates B3GNT6-mediated Tn-specific labelling, click chemistry, and chemiluminescence detection to enable quantitative and sensitive analysis of Tn antigen.
Authors
- Mingliang Ye (ORCID: https://orcid.org/0000-0002-5872-9326)
- Jia Li (ORCID: https://orcid.org/0000-0003-3152-3253)
- Yan Wang
- Lei Liu
- Xin Guo
- Zhongyu Wang
- Huizhen Huang
- Mingming Dong
- Yanan Li
- Zheng Fang
- Hui Zhang
- Hongxia Duan
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1039/d5cc05398f
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00