Effect of the rs7858836 Single‐Nucleotide Polymorphisms of the <scp> <i>ASTN2</i> </scp> Gene on Pain‐Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery
The minor T allele of the rs7858836 SNP was significantly associated with lower postoperative pain intensity, albeit only slightly, and decreased the need for rescue analgesics under comparable fentanyl dosing conditions, potentially reflecting lower pain sensitivity. However, the magnitude of the effect was less than our previous findings.
Authors
- Rie Inoue (ORCID: https://orcid.org/0000-0001-6371-9491)
- Masakazu Hayashida (ORCID: https://orcid.org/0000-0002-3598-2281)
- Kazutaka Ikeda (ORCID: https://orcid.org/0000-0001-9247-4593)
- Hisako Okada (ORCID: https://orcid.org/0000-0001-7294-7197)
- Atsuko Hara (ORCID: https://orcid.org/0000-0002-4019-4212)
- Yuko Ebata
- Shoko Okahara (ORCID: https://orcid.org/0000-0002-7393-9866)
- Kyoko Nakayama
- Junko Hasegawa (ORCID: https://orcid.org/0000-0002-7545-7983)
- Daisuke Nishizawa (ORCID: https://orcid.org/0009-0003-1751-9300)
Institutions
- Juntendo University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- National Center of Neurology and Psychiatry (JP)
- National Institute of Mental Health (JP)
Publication Details
- Journal
- Neuropsychopharmacology Reports
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1002/npr2.70083
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Research Foundation for Clinical Pharmacology
- Smoking Research Foundation
- Japan Society for the Promotion of Science