Verteporfin, an inhibitor of nuclear YAP, improved multi-ciliated cell differentiation in the airway epithelium
Our findings suggest YAP nuclear localization in human airway MCCs is broadly associated with decreased MCCs regardless of patient condition, and verteporfin improves airway MCC differentiation.
Authors
- Ryô Nakamura (ORCID: https://orcid.org/0000-0002-0761-0704)
- Tomoko Kita (ORCID: https://orcid.org/0000-0003-3457-0119)
- Yo Kishimoto
- Koichi Omori
- Yukiko Okuno
- Shinji Kaba
- Susumu Yoshie
Institutions
- Fukushima Medical University (JP)
- Kyoto University (JP)
- Kyoto Pharmaceutical University (JP)
- Kyoto University Hospital (JP)
- New York University (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12967-025-07250-3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00