Zn-Mediated Cross Coupling of Alkynyl Bromides and Polychlorosilanes
A Zn-mediated, transition-metal- and ligand-free synthesis of alkynylsilanes from alkynyl bromides and polychlorosilanes is reported. A wide range of alkynyl bromides and chlorosilanes, including monochlorosilanes, afford alkynylsilanes in moderate to excellent yields. The products allow for diverse downstream functionalization. Control experiments and DFT calculations support an S<sub>N</sub>2-type substitution pathway involving an alkynylzinc intermediate and chlorosilanes. This protocol offers a practical and general approach to access diverse alkynylsilanes from readily accessible precursors.
Authors
- Yan-Lin Zhang (ORCID: https://orcid.org/0000-0002-8722-8635)
- Xiaoting Zou (ORCID: https://orcid.org/0009-0007-5888-4004)
- Liangquan Sheng
- Xi Chen
- Pan Pan
- Huajie Xu
- Wenwen Huang
- Jingcao Li
Institutions
- Fuyang Normal University (CN)
- Southern University of Science and Technology (CN)
- Biomass Technology Group (Netherlands) (NL)
- Jiangmen Polytechnic (CN)
- State Key Laboratory of Applied Organic Chemistry
- Lanzhou University (CN)
- Green Cross International (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1021/acs.joc.5c02374
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00